Amy Orsborn, who will join UW in January 2018 as the Clare Booth Luce Assistant Professor in Electrical Engineering and Bioengineering, discusses her work in improving brain-computer interfaces and offers advice to women in STEM.
Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers
Yilong Chen, Drew L. Sellers, James-Kevin Y. Tan, David J. Peeler, Philip J. Horner, Suzie H. Pun. Biomaterials. Volume 127, May 2017, Pages 89-96. The researchers report a pH-sensitive polymer, p(PMA-PMBA)-b-p(OEGMA-DMAEMA) (SP), and its successful use in vitro and in vivo gene transfer. The polymer addresses the dilemma of stability and cargo release in gene delivery, and may have broad potential therapeutic agent delivery applications.
J.P. Esquivel, J.R. Buser, C.W. Lim, C. Domínguez, S. Rojas, P. Yager, N. Sabaté. Journal of Power Sources. Volume 342, 28 February 2017, Pages 442-451. The researchers demonstrate a stand-along power source that integrates a paper-based hydrogen fuel cell with a customized chemical heater that produces hydrogen in-situ upon the addition of a liquid. Their approach could power portable diagnostics and enable functionality such as device timing, actuation and signal quantification.
miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria
Kevin R Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L Conroy, Michael Hawkes, Henry S Cheng, Makon-Sébastien Njock, Jason E Fish, John M Harlan, Jose A López, W Conrad Liles, and Kevin C Kain. Molecular Medicine. 2017 February 2; 23. The researchers demonstrate that miR-155 has a mechanistic role in host response to malaria via regulation of endothelial activation, microvascular leak and blood brain barrier (BBB) dysfunction in cerebral malaria (CM).
Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo
Yuandong Li, Woo June Choi, Wan Qin, Utku Baran, Lauren M. Habenicht, Ruikang K. Wang. Journal of Neuroscience Methods. Volume 274, 1 December 2016, Pages 164-172. The researchers demonstrate that optical coherence tomography (OCT)-based microangiography (OMAG) is a promising imaging tool for longitudinal study of collateral vessel remodeling in small animals, and can be applied in guiding the in-vivo experiments of arteriogenesis stimulation to treat occlusive vascular diseases, including stroke.
In this issue: Innovation and Impact | Student Highlights | Alumni Highlights | Community Highlights [...]
Northwest Kidney Centers announces gift to UW over 5-year span SEATTLE, Wash. (March 13, 2017): [...]
Efren Lee aims to advance PET/CT imaging technology to help physicians better plan and evaluate the success of individualized treatment, and to improve patient outcomes. Efren works with Paul Kinahan, UW professor of radiology and adjunct faculty in BioE, in the Imaging Research Laboratory.
Eric Chudler interviewed by KING 5’s New Day Northwest about “Brain Bytes: Quick Answers to Quirky Questions About the Brain”
Eric Chudler, research associate professor of bioengineering and executive director of the Center of Sensorimotor [...]
The BCTG provides an opportunity for graduate students interested in cardiovascular science and engineering to train under the guidance of excellent mentors. Application deadline: Friday, April 14, 2017.