Alec S. T. Smith, Hyok Yoo, Hyunjung Yi, Eun Hyun Ahn, Justin H. Lee, Guozheng Shao, Ekaterina Nagornyak, Michael A. Laflamme, Charles E. Murry and Deok-Ho Kim. Chemical Communications, 2017, 54, 7412-7415. Dr. Kim and colleagues demonstrate a method for producing cardiac tissue scaffolds with anisotropic electroconductive properties using PEG-graphene substrates.
Shichu Huang , Koji Abe, Steven Bennett, Tinny Liang, Paula D. Ladd, Lindsay Yokobe, Caitlin E. Anderson, Kamal Shah, Josh Bishop, Mike Purfield, Peter C. Kauffman, Sai Paul, AnneMarie E. Welch, Bonnie Strelitz, Kristin Follmer, Kelsey Pullar, Luis Sanchez-Erebia, Emily Gerth-Guyette, Gonzalo Domingo, Eileen Klein, Janet A. Englund, Elain Fu and Paul Yager. Analytical Chemistry, 2017, 89 (11), 5776-5783. The researchers demonstrate a prototype of a self-contained, automated, disposable device for chemically amplified protein-based detection of influenza virus from nasal swab specimens. The device was tested in a clinical setting and was well received by patients and clinicians, further inspiring further optimization of the device.
Chitosan enhances nanoparticle delivery from the reproductive tract to target draining lymphoid organs
Jaehyung Park, Renuka Ramanathan, Linhchi Pham, Kim Woodrow. Nanomedicine: Nanotechnology, Biology and Medicine, Volume 13, Issue 6, August 2017, 2015-2025. The researchers propose a method to achieve enhanced immune response against viral infections in the female reproductive tract. They demonstrate that intravaginal pre-treatment with chitosan significantly facilitates translocation of nanoparticles across the the multilayered vaginal epithelium to target draining lymph nodes.
Synthetic Macromolecular Antibiotic Platform for Inhalable Therapy against Aerosolized Intracellular Alveolar Infections
Debobrato Das, Jasmin Chen, Selvi Srinivasan, Abby M. Kelly, Brian Lee, Hye-Nam Son, Frank Radella, T. Eoin West, Daniel M. Ratner, Anthony J. Convertine, Shawn J. Skerrett and Patrick S. Stayton. Molecular Pharmaceutics, 2017, 14 (6), 1988-1997. The researchers demonstrate a macromolecular therapeutic platform that provides sustained local delivery of ciprofloxacin. Their work addresses the unmet need for inhaled treatments for lung-based intracellular bacterial infections such as Franciscella tularensis pneumonia (tularemia), which are currently treated with oral or IV antibiotics that poorly achieve and sustain pulmonary drug bioavailability.
Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
Arja Ray, Oscar Lee, Zaw Win, Rachel M. Edwards, Patrick W. Alford, Deok-Ho Kim and Paolo P. Provenzano. Nature Communications, 8, 1493 (2017). The researchers investigate whole cell and molecular level interactions that mediate contact guidance of phenotypically distinct carcinoma cells. By using nano-patterning techniques to produce substrates that facilitate detailed analysis, they identify a cellular mechanism of topographic sensing that can account for the diversity of responses across multiple cell phenotypes.
Fibroblast-specific genetic manipulation of p38 MAPK in vivo reveals its central regulatory role in fibrosis
Jeffery D. Molkentin, Darrian Bugg, Natasha Ghearing, Lisa E. Dorn, Peter Kim, Michelle A. Sargent, Jagadambika Gunaje, Kinya Otsu, Jennifer M. Davis. Circulation, July 11, 2017, Volume 136, Issue 2. The researchers examine the role of mitogen-activated protein kinase (MAPK) p38a (Mapk14) gene in orchestrating the fibroblast differentiation and fibrosis involved in cardiac injury response.
David Castner receives 2017 European Conference on Applications of Surface and Interface Analysis Award
David Castner is recognized for his outstanding scientific achievements and contributions to the study, analysis and understanding of biological and biomedical interfaces.
Assistant Professor Deok-Ho Kim has been featured in the 2017 Emerging Investigators Issue of Chemical Communications, a journal of the Royal Society of Chemistry. In Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering, Dr. Kim and colleagues demonstrate a method for producing cardiac tissue scaffolds with anisotropic electroconductive properties using PEG-graphene substrates.
The journal Biointerphases recognizes David Castner's scholarly, editorial contributions; celebrates Buddy Ratner's 70th birthday
In this issue: Innovation and Impact | Trainee Highlights | Alumni Highlights | Community Highlights | Featured Publications Have [...]