Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
Ying Zheng and colleagues demonstrate that engineered perfusable microvessel grafts enhance vascular remodeling and accelerate coronary perfusion, potentially supporting cardiac tissues after implantation.
Scaffold-Mediated Delivery for Non-Viral MRNA Vaccines
SCAFFOLD-MEDIATED DELIVERY FOR NON-VIRAL MRNA VACCINES https://www.nature.com/articles/s41434-018-0040-9 Ruying Chen, Hong Zhang, Jingxuan Yan, James D. Bryers Nature: Gene Therapy volume 25, pages556–567 (2018) ABSTRACT mRNA is increasingly being recognized as a promising alternative to pDNA in gene vaccinations. [...]
Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells
Kim Woodrow and colleagues demonstrate a LCNP that has the potential to co-deliver ARVs and mAbs for eradicating HIV reservoirs.
Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy
Ruikang Wang and colleagues demonstrate that swept-source OCTA may represent a new and noninvasive method for detecting and monitoring disease activity in BSCR.
Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates
Charles Murry and colleagues demonstrate that remuscularization of the infarcted macaque heart with human myocardium provides durable improvement in left ventricular function.
Cationic polymers for non-viral gene delivery to human T cells
Suzie Pun and colleagues We demonstrate transfection of both CD4+ and CD8+ primary human T cells with messenger RNA and plasmid DNA at efficiencies up to 25 and 18%, respectively, with similarly high viability.