Featured Publications from UW Bioengineering
Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers
The researchers report a pH-sensitive polymer, p(PMA-PMBA)-b-p(OEGMA-DMAEMA) (SP), and its successful use in vitro and in vivo gene transfer. The polymer addresses the dilemma of stability and cargo release in gene delivery, and may have broad potential therapeutic agent delivery applications.
The researchers demonstrate a stand-along power source that integrates a paper-based hydrogen fuel cell with a customized chemical heater that produces hydrogen in-situ upon the addition of a liquid. Their approach could power portable diagnostics and enable functionality such as device timing, actuation and signal quantification.
miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria
The researchers demonstrate that miR-155 has a mechanistic role in host response to malaria via regulation of endothelial activation, microvascular leak and blood brain barrier (BBB) dysfunction in cerebral malaria (CM).
Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo
The researchers demonstrate that optical coherence tomography (OCT)-based microangiography (OMAG) is a promising imaging tool for longitudinal study of collateral vessel remodeling in small animals, and can be applied in guiding the in-vivo experiments of arteriogenesis stimulation to treat occlusive vascular diseases, including stroke.
Facile fabrication of tissue-engineered constructs using nanopatterned cell sheets and magnetic levitation
The researchers describe a novel method for fabricating scaffold-free tissue-engineered constructs using thermoresponsive nanofabricated substrates (TNFS) and magnetic levitation.
The researchers demonstrate acoustic micro-tapping – the use of focused ultrasound propagating in air to generate transient mechanical waves – as a non-invasive approach to dynamic elastography for mapping the elasticity of biological tissue without any physical contact. They propose to use it with 4-D phase-sensitive optical coherence tomography to create a tool for ophthalmology, dermatology and other applications where direct contact with the tissue being studied may be undesirable.
Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation
The researchers investigate the importance of Runx2 (runt-related transcription factor-2) in turning vascular smooth muscle cells into bone and cartilage cells, contributing to arterial intimal calcification, a condition implicated in atherosclerosis and may contribute to heart attack, stroke and other cardiovascular events.
The researchers demonstrate a prototype of MAD NAAT, the first fully integrated, sample-to-result diagnostic platform for performing nucleic acid amplification texts that require no permanent instrument or manual sample processing.
Microvascular Injury and Perfusion Changes Induced by Ultrasound and Microbubbles in a Machine-Perfused Pig Liver
The researchers combined ex vivo machine-perfused pig livers with an image-guided therapy system to investigate applications of ultrasound-driven microbubbles to enhance drug delivery, and demonstrate a versatile, physiologically relevant platform for pre-clinical research.
The researchers describe an fMRI processing and analysis framework for multiecho fetal brain studies where head motion cannot be controlled.