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INVENTING THE FUTURE OF MEDICINE

Marta Scatena

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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Research Associate Professor Marta Scatena and a team of collaborators show that raising Sphingosine-1-phosphate (S1P) levels in adult mice through conditionally deleting or pharmacologically inhibiting S1P lyase, the sole enzyme responsible for irreversibly degrading S1P, markedly increased bone formation, mass and strength and substantially decreased white adipose tissue.

By |2021-01-08T06:08:43-08:00July 4th, 2018|

Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model

The Scatena and Giachelli labs developed an animal model that mimicked the structural and functional features of CAVD in people with T2DM, by testing a diabetogenic, procalcific diet and its effect on the incidence and severity of CAVD and AS in the, LDLr-/-ApoB100/100 mouse model.

By |2021-01-08T06:09:10-08:00March 16th, 2018|
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