Cell migration in health and disease: unraveling the guiding principles for complex environments
Director of the Yale Systems Biology Institute, John C. Malone Professor of Biomedical Engineering
April 20, 2017
12:30 p.m. - 1:20 p.m.
Foege N130A, Wallace H. Coulter Seminar Room
Cell migration has been the focus of analysis for both cell and tissue biologists and engineers for close to a century. However, only recently, a range of tools have become available to study it in deep quantitative detail. Furthermore, new biochemical methods can now help re-engineer and enforce the cell migration behavior. In this talk, I will illustrate our own contributions to these exciting developments, focusing on how the marriage of microfabrication, genetic, biochemical, cell imaging and mathematical tools has proven to be especially illuminating. I will then focus on the more recent developments revealing the responses of cells to complex, often conflicting, cues in the contexts as diverse as invasive cancer spread and neuronal network development.
Andre Levchenko is a John C. Malone Professor of Biomedical Engineering, the Founding Director of the Yale Systems Biology Institute and the Director of Yale Cancer Systems Biology Center (CaSB@Yale). Before moving to Yale in 2013, he spent 12 years as faculty at Johns Hopkins University, achieving the rank of the full Professor of Biomedical Engineering there. His labs at Hopkins and Yale have focused on development of new approaches to understanding cell signaling and cell-cell communication, in particular through development of new micro- and nano-fabricated devices and new mathematical and computational techniques. Before his faculty position at Hopkins, Prof. Levchenko did his post-doctoral work at Caltech, working with a mix of faculty ranging from genetics to computer science. Before this, he got his doctoral degree at Columbia University among the first class of the BME program there, while also working on his thesis at the Memorial Sloan-Kettering Cancer Center. Prof. Levchenko arrived in the United States as a refugee with his family, following his undergraduate degree at Moscow Institute for Physics and Technology, where he majored in Theoretical Biophysics. Prof. Levchenko is a Fellow of American Physical Society and of the American Institute for Medical and Biological Engineering. He was elected a member of the Connecticut Academy of Science and Engineering.