Simple Tools for Probing the Nanoscale Organization of Cells and Tissues with Super-Resolution Fluorescence Microscopy
Assistant Professor, Chemistry; Adjunct in Physiology and Biophysics
University of Washington
February 8, 2018
Foege N130A, Wallace H. Coulter Seminar Room
My group develops chemical tools for high resolution fluorescence microscopy and we use these tools to understand the organization of biological systems in their native cellular and tissue contexts. Many of our projects make use of super-resolution fluorescence microscopy methods in order to peer beneath the ~250 nm diffraction-limited resolution of traditional fluorescence microscopy and to interrogate nanoscale features of biological specimens with rich molecular detail. In my talk, I will discuss our recent efforts in developing methods to image cultured cells, model organisms, and human tissue.
Prof. Vaughan grew up in the San Francisco bay area and later studied chemistry at Reed College in Portland, OR where he first fell in love with the Pacific Northwest. He earned a Ph.D. in physical chemistry at MIT where he worked in the lab of Keith Nelson on applications of adaptive optics to ultrafast spectroscopy. For his postdoctoral research in Xiaowei Zhuang’s lab at Harvard he studied virus transport and developed tools for super-resolution fluorescence microscopy. His current interests include developing new tools to extract molecular detail from intact biological specimens and applying these tools to important biological questions.