The Many Roles of Modeling and Simulation in Biomedical Sciences: From Kinetic Analysis to Systems Pharmacology
Dr. Paolo Vicini
Pfizer Global Research and Development
January 30, 2014
12:30 - 1:30 p.m.
Foege N130A, Wallace H. Coulter Seminar Room
Computer modeling and simulation has an important and growing role in the interpretation of measurements and data from biology. This is true both in academic basic sciences and in pharmaceutical research, where computer modeling approaches to translational research are becoming critical to integrate preclinical and clinical observations in the pursuit of successful drug candidates – specifically, safe, effective, and valuable medicines for patients and prescribers that meet medical needs. Modern approaches to translational modeling find their origin in large-scale integrative physiology and systems biology problems, and aim at bringing together micro- and macro-scale phenomena at seemingly opposite ends of the spectrum. This seminar will provide a current perspective on the emergence of modeling and simulation as a key discipline in pharmaceutical translational research. Collaboration across areas (including biology, medicinal chemistry and laboratory medicine) and potential relevance to students will be addressed. Case study examples will be included.
Paolo Vicini received his Ph.D. (Bioengineering) from the Polytechnic of Milan, Italy, in 1996. He joined the University of Washington faculty in 1998 as a Research Assistant Professor and became an Associate Professor of Bioengineering in 2004. His work at the University of Washington was on the development of data analysis software and the application of modeling and simulation techniques to diabetes, cancer, pharmacokinetics and pharmacodynamics. In 2008, he joined Pfizer Worldwide Research and Development in San Diego, CA, as a Research Fellow in the Pharmacokinetics, Dynamics and Metabolism Department. His current research focuses on translational modeling and simulation in support of various discovery programs. He is currently pursuing a MBA degree with the University of Southern California.