Patient-specific Analysis of Hip Biomechanics: Studies of Dysplasia and Femoracetabular Impingement
Jeffrey A. Weiss
rofessor of Bioengineering, Adjunct Professor in the School of Computing, Adjunct Professor of Orthopedics, and Faculty Member in the Scientific Computing and Imaging Institute
Bioengineering, University of Utah
January 8, 2015
Foege N130A, Wallace H. Coulter Seminar Room
Most cases of hip osteoarthritis (OA) are now believed to be caused by alterations in joint mechanics resulting from pathomorphologies such as acetabular dysplasia and femoroacetabular impingement. Over the past 14 years, our research group has focused on developing approaches for patient-specific modeling of cartilage and labrum in the human hip, and applying these approaches to study hip pathomorphology. The long term objective is to improve the understanding of the etiology of OA related to hip pathomorphology, and to improve diagnosis and treatment. The objectives of this presentation are to provide a summary of our subject-specific modeling approach, to describe our findings related to acetabular dysplasia and femoroacetabular impingement, and to highlight the significance of the findings related to the etiology, diagnosis and treatment of pathomorphologic hips.
Professor Weiss received his bachelor’s and master’s degrees in Bioengineering at the University of California, San Diego, his doctorate in Bioengineering at the University of Utah in 1994, and completed postdoctoral training with the Applied Mechanics Group at Lawrence Livermore National Laboratory (1995-96). He holds the titles of Professor of Bioengineering, Adjunct Professor in the School of Computing, Adjunct Professor of Orthopedics, and Faculty Member in the Scientific Computing and Imaging Institute at the U of Utah. Weiss’ research efforts have focused on the areas of experimental and computational biomechanics, primarily applied to the musculoskeletal and cardiovascular soft tissues. He developed and validated techniques for subject-specific computational modeling of joint mechanics, and applied these techniques to the mechanics of knee ligaments and patient-specific modeling of mechanics in the hip. Fundamental studies of ligament mechanics have included constitutive modeling, elucidation of ligament in situ strains, characterization of multiaxial viscoelastic material behavior, characterization of structure-function relationships, and determining the structural role of non-collagenous components, including decorin proteoglycans and elastin. Prof. Weiss also developed finite-element based techniques to incorporate medical image data directly into biomechanics analyses for strain measurement. His current research interests include the mechanics of angiogenesis, the development of patient-specific analysis methods for joint and tissue mechanics, and the development of distribution of software for computational biomechanics. Professor Weiss’s lab develops, distributes and supports FEBio, an open-source finite element software suite for computational biomechanics (febio.org). Prof. Weiss has received a number of highly coveted honors, including a Whitaker Foundation Research Grant (1995), a NSF CAREER Award (2002), the ASME YC Fung Young Investigator Award (2002), election to Fellow of the AIMBE (2006), the ASME Van C. Model Medal (2013), and several Best Paper awards.