Light and Sound for Biomedical Diagnostics and Therapy
Tatiana D. Khokhlova (Imaging Faculty Candidate)
Department of Medicine, Division of Gastroenterology, UW
May 15, 2014
Foege N130A, Wallace H. Coulter Seminar Room
This talk will be focused on two particular biomedical applications of light and sound – high intensity focused ultrasound (HIFU) therapy and photoacoustic (PA) imaging. HIFU is an emerging medical technology most commonly used to perform non-invasive thermal ablation of tissues. Alternatively, the activity of HIFU-induced bubbles may be used to mechanically disrupt or, at its extreme, locally fractionate tissue and turn it into fluid-like homogenate. In this talk, I will describe how these mechanical effects may be induced and controlled in two specific clinical applications: chemotherapeutic drug delivery to tumors and stimulation of cancer biomarker release for disease diagnosis and staging.
In photoacoustics tissue is illuminated and instantly heated by a laser beam, which leads to transient thermal expansion and excitation of ultrasound signals in tissue. Detection of the signals allows to visualize structures with enhanced optical absorption such as blood, melanin, and thermal lesions. Intense interest to this area in recent years has led to discovery of many potential applications and multiple instrumental developments such as small animal imaging systems and clinical breast imaging systems. This presentation will address PA imaging of tissues at larger depths (up to several centimeters) and will include the details on receiving transducer design and image reconstruction algorithms.
Dr. Tatiana Khokhlova is an Acting Instructor in the laboratory of Dr. Joo Ha Hwang at the Department of Medicine, University of Washington. Her research interests lie in the areas of focused ultrasound therapy and biomedical applications of photoacoustic imaging. Dr. Khokhlova’s most recent work was targeted at the development of the novel method of soft tissue erosion by focused ultrasound and its application to tumor ablation and stimulation of cancer biomarker release. She received a mentored Career Development Award from NIH (K01) in 2012 to support this research. Before her time at the University of Washington, she obtained her PhD in Physics in 2008 from M.V. Lomonosov Moscow State University under the supervision of Alexander Karabutov. For her PhD she worked on the image reconstruction algorithms and the design of array transducers for photoacoustic tomography.