All-Optical Cardiac Electrophysiology
Biomedical Engineering, Stony Brook University
May 21, 2015
Foege N130A, Wallace H. Coulter Seminar Room
Optical targeting (stimulation or recording) allows distributed parallel access to thousands and even millions of cells and locations at the same time, and within the tissue setting; it enables new functional interrogation technology that is high-throughput by nature and with direct applicability to cardiac electrophysiology. In this talk, I will discuss and demonstrate the combination of optogenetic stimulation with optical imaging of electrical activity in cardiomyocytes, i.e. the realization of “all-optical electrophysiology” in a high-throughput (HTS) manner.
Dr. Emilia Entcheva is a Professor of Biomedical Engineering at Stony Brook University with joint appointments in Physiology and Biophysics and Cardiology. Since 2001, she directs the Cardiac Optogenetics and Optical Imaging Laboratory in Stony Brook. Her research group has contributed to the development of new tools for optical mapping of cardiac excitation, innovative techniques to engineering cardiac tissue and its functional characterization using lab-on-a-chip platforms, computational modeling of cardiac electrophysiology, and has spearheaded efforts in cardiac optogenetics and the development of highly-parallel all-optical cardiac electrophysiology.