Molecular Understanding, Design and Development of Zwitterionic-based Biomaterials
Boeing-Roundhill Professor of Chemical Engineering and Adjunct Professor of Bioengineering
Chemical Engineering, University of Washington
October 2, 2014
12:30 - 1:30 p.m.
Foege N130A, Wallace H. Coulter Seminar Room
An important challenge in many applications, ranging from biomedical devices to drug delivery carriers, is the prevention of nonspecific biomolecular and microorganism attachment on surfaces. To address this challenge, our goals are twofold. First, we strive to provide a fundamental understanding of nonfouling mechanisms at the molecular level using an integrated experimental and simulation approach. Second, we aim to develop biocompatible and environmentally benign ultra low fouling materials based on the molecular principles we have learned. Over the last several years, we have demonstrated that zwitterionic and mixed charge materials and surfaces are highly resistant to nonspecific protein adsorption, cell adhesion and bacteria adhesion/biofilm formation from complex media. Recent results show that zwitterionic materials induce no capsule formation upon implantation and no immunological response in blood circulation and are able to preserve protein bioactivity and maintain stem cells in their native states. At present, zwitterionic materials have been applied to a number of applications, including implantable medical devices, diagnostics, drug/gene delivery, antimicrobial coatings, and marine coatings as alternatives to poly(ethylene glycol) (PEG)-based materials.
Professor Jiang received his Ph.D. degree in chemical engineering from Cornell University. He was a postdoctoral fellow at UC Berkeley and a research fellow at Caltech both in chemistry. Currently, he is Boeing-Roundhill Professor of Chemical Engineering and Adjunct Professor of Bioengineering at the University of Washington, Seattle. He is a senior editor for Langmuir, a fellow of the American Institute for Medical and Biological Engineering (AIMBE), a fellow of the American Institute of Chemical Engineers (AIChE) and a member of the Washington State Academy of Sciences. His research focuses on biomolecular interfaces and biomaterials.