Project Description

Professor Emeritus
Not accepting graduate students
Phone: (201)440-5360

Smart polymers and hydrogels
Polymeric biomaterials
Surface energy principles
Surface modification
Protein adsorption
Non-fouling surfaces
Controlled drug delivery

Dr. Hoffman is an international “ambassador for biomaterials.” After joining the UW faculty in 1970, he began to synthesize polymers and hydrogels with special physical and biomedical properties. By combining these special biomaterials with drugs, enzymes and antibodies, he pioneered the applications of temperature and pH-responsive intelligent polymers and hydrogels in the fields of drug delivery, diagnostic assays and biologically-active and non-fouling polymer surfaces. Much of his research has been carried out with Department of Bioengineering collaborators Buddy Ratner, Thomas Horbett and Patrick Stayton. Dr. Hoffman is inventor or co-inventor on  273 patent applications, of which 113 were issued; several of these were licensed to industry.

Dr. Hoffman continues to actively teach in short courses in the US and internationally, and to advise on research in the areas of smart polymers and hydrogels, controlled drug delivery, separations and biomaterial surface modification.

BS, MS and ScD, Chemical Engineering, MIT, 1949-1957

President, Society for Biomaterials (1983-1984)
Biomaterials Science Prize, Japanese Biomaterials Society (1990)
Founder’s Award of the Society for Biomaterials (2000)
Chandra Sharma Award, Biomaterials Society of India (2003)
Elected to the US National Academy of Engineering (2005)
International Recognition Award, Society for Polymer Science, Japan (2006)
Founder’s Award of the Controlled Release Society (2007)
Acta Biomaterialia Gold Medal (2017)

Dr. Hoffman previously taught courses on surface principles, polymer structure-properties relationships, biomaterials and drug delivery systems.

AS Hoffman, Historical Introduction to the Field of Drug Delivery and Targeting; invited as the introductory chapter in the book: “Drug Delivery and Targeting Fundamentals, Applications and Future Directions”, 2nd Edition, Taylor and Francis, London (to be published in 2016).

R Namgung, YM Lee, J Kim, Y Jang, BH Lee, IS Kim, P Sokkar, YM Rhee, AS Hoffman and WJ Kim, Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy, Nature Comm 5:3702 (2014).

M Ebara, JM Hoffman, AS Hoffman, PS Stayton, and JJ Lai, A Photo-induced Nanoparticle Separation in Microchannels via pH-sensitive Surface Traps, Langmuir 29, 5388?5393  (2013)

MA Nash, JN Waitumbi, AS Hoffman, P Yager, and PS Stayton. Multiplexed Enrichment and Detection of Malarial Biomarkers Using a Stimuli-Responsive Iron Oxide and Gold Nanoparticle Reagent System, ACS Nano 6, 6776–6785 (2012)

Hoffman J, Stayton PS, Hoffman AS, Lai J-i, Ebara M, Folch A. Protein-Polymer Conjugate Capture, Enrichment and Release in “Smart” Microchannels, Lab Chip (2010)

Duvall CL, Convertine AJ, Benoit DS, Hoffman AS, Stayton PS. “Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT-Synthesized Endosomolytic Polymer”, Molecular Pharm., 7, 468-472 (2010)

Lai, J., Hoffman, A.S., and Stayton, P.S., “Dual Magnetic-Temperature Responsive Nanoparticles for Microfluidic Separations and Assays”, Langmuir, 23, 7385-7391 (2007)

Kulkarni, C. Schilli, B. Grin, A.H.E. Müller, A.S. Hoffman, and P.S. Stayton, “Controlling the Aggregation of Conjugates of Streptavidin with Smart Block Copolymers Prepared via the RAFT Copolymerization Technique”, Biomacromol., 7, 2736-41 (2006)

Malmstadt, A.S. Hoffman and P.S. Stayton, “Smart Mobile Affinity Matrix for Microfluidic Immunoassays”, Lab Chip, 4, 412-415 (2004)

Malmstadt, D. Hyre, Z. Ding, A.S. Hoffman and P.S. Stayton, “Affinity Thermoprecipitation and Recovery of Biotinylated Biomolecules via a Mutant Streptavidin-Smart Polymer Conjugate”, Bioconj. Chem., 14, 575-580 (2003)

Shimoboji, E. Larenas, T. Fowler, S. Kulkarni, A.S. Hoffman and P.S. Stayton, “Photoresponsive polymer-enzyme switches”, PNAS, 99 16592-6 (2002)

A.S. Hoffman, Hydrogels for Biomedical Applications, Adv. Drug Del. Revs, 43 (2002) 3-12. (This was the most highly cited article in ADDR for 2002)

Ding, R.B. Fong, C.J. Long, A.S. Hoffman, and P.S. Stayton, Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield, Nature 411 (2001) 59-62.

P.S. Stayton, T. Shimoboji, C. Long, A. Chilkoti, G. Chen, J.M. Harris and A.S. Hoffman, Control of protein-ligand recognition using a stimuli-responsive polymer, Nature 378 (1995) 472-474.

G.H. Chen, and A.S. Hoffman, Graft copolymer compositions that exhibit temperature-induced transitions over a wide range of pH, Nature 373 (1995) 49-52.

Hoffman, A.S., T.A. Horbett and B.D. Ratner, “Interactions of Blood and Blood Components”, Ann. N.Y. Academy of Sciences,  283, 372 (1977).

Ratner, B.D. and A.S. Hoffman, “Synthetic Hydrogels for Biomedical Applications”, ACS Symposium Series,  31, “Hydrogels for Medical and Related Applications”, 1-36 (1976).

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