Project Description

Research Associate Professor
Phone: (206)221-5168
Office: Foege N510F
UW Bioengineering faculty James Lai

James Lai

In order to improve the future health care, better clinical assays are require to detect biomarkers for the diagnosis, prognosis, and therapeutic management of human disease. The outcome of my research can potentially generate molecular reagents to improve sensitivity, specificity, and the capability to detect multiple biomarkers of the clinical assays.
Global health
In vitro diagnostic assays
Stimuli-responsive polymers
Protein conjugates
Biomolecule separation
The focus of my research is the development of molecular reagents for the applications in biomolecule separation and diagnostic assays. The overall objective is to improve assays’ sensitivity, specificity, throughput, and multiplexing capacity. My group has been developing new stimuli-responsive reagent systems with different stimuli and reagent formats (e.g., nanoparticles and conjugates) to interface with various analytical technologies to facilitate the corresponding diagnostic applications.
PhD, Chemical Engineering, Polytechnic University, 2005
MS, Chemical Engineering, Polytechnic University, 2003
BS, Chemical Engineering, University of Minnesota, 1999
AD, Chemical Engineering, National Taipei Institute of Technology, Taiwan, 1995
Postdoctoral Fellow, Department of Bioengineering, University of Washington, 2005-2009
2004 Ticona Award, Polytechnic University
2000-2004 Robert Tsao Endowment Fellowship, Polytechnic University
Ebara M, Hoffman JM, Hoffman AS, Stayton PS, Lai JJ. A photoinduced nanoparticle separation in microchannels via pH-sensitive surface traps. Langmuir. 2013;29(18):5388-93.

Chang MY, Yang YJ, Chang CH, Tang AC, Liao WY, Cheng FY, Yeh CS, Lai JJ, Sayton PS, Hsieh PC. Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. J Control Release. 2013;170(2):287-94.

Roy D, Nehilla BJ, Lai JJ, Stayton PS. Stimuli-responsive polymer-antibody conjugates via RAFT tetrafluorophenyl active ester chemistry. ACS Macro Letters. 2013;2(2): 132-136.

Golden AL, Battrell CF, Pennell S, Hoffman AS, Lai JJ, Stayton PS. Simple fluidic system for purifying and concentrating diagnostic biomarkers using stimuli-responsive antibody conjugates and membranes. Bioconjug Chem. 2010;21(10):1820-6.

Hoffman JM, Ebara M, Lai JJ, Hoffman AS, Folch A, Stayton PS. A helical flow, circular microreactor for separating and enriching “smart” polymer-antibody capture reagents. Lab Chip. 2010;10(22):3130-8.

Nash MA, Lai JJ, Hoffman AS, Yager P, Stayton PS. “Smart” diblock copolymers as templates for magnetic-core gold-shell nanoparticle synthesis. Nano Lett. 2010;10(1):85-91.

Lai JJ, Nelson KE, Nash MA, Hoffman AS, Yager P, Stayton PS. Dynamic bioprocessing and microfluidic transport control with smart magnetic nanoparticles in laminar-flow devices. Lab Chip. 2009;9(14):1997-2002.

Lai JJ, Hoffman JM, Ebara M, Hoffman AS, Estournes C, Wattiaux A, et al. Dual magnetic-/temperature-responsive nanoparticles for microfluidic separations and assays. Langmuir. 2007;23(13):7385-91.

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