UW Bioengineering
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News and Events
Building innovation through mentorship
In the rapidly evolving field of bioengineering, the bridge between [...]
Events
Faculty Promotions: Andre Berndt and Patrick Boyle
UW Bioengineering is thrilled to congratulate faculty members Andre Berndt and Patrick Boyle on their promotions to associate professors with tenure
Ayokunle Olanrewaju receives prestigious Beckman Young Investigator Award
The Arnold and Mabel Beckman Foundation awarded UW BioE and ME Assistant Professor Ayokunle (Ayo) Olanrewaju with the Beckman Young Investigator Award.
NIH provides major support to CRBM for advancing reproducible biomedical modeling
The National Institute of Biomedical Imaging and Bioengineering has committed a multi-million-dollar grant to support the CRBM at the University of Washington.
News & Events
Featured Publications
A Carboxylate to Amide Substitution That Switches Protein Folds
Valerie Daggett and colleagues performed a comparative molecular dynamics study on the denatured states of two proteins, sharing nearly identical amino?acid sequences (88?%) but different topologies, namely an all?a?helical bundle protein named GA88 and an a+B?protein named GB88.
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
The researchers achieved high-throughput, quantitative characterization of protein–protein binding interactions without requiring purified recombinant proteins, by linking interaction strength with yeast mating. Using a next-generation sequencing output, they characterized protein networks consisting of thousands of pairwise interactions in a single tube and have demonstrated the effect of changing the binding environment.
Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue
The researchers demonstrate the application of crosslinking mass spectrometry to identify protein structural features and interactions in tissue samples, providing systems structural biology insight into protein complexes as they exist in the mouse heart. The extension of crosslinking mass spectrometry analysis into the realm of tissues opens the door to increasing understanding of protein structures and interactions within the context of the greater biological system.
