Fund Black Scientists
Commentary with lead author Kelly Stevens: Our nationwide network of BME women faculty collectively argue that racial funding disparity by the National Institutes of Health (NIH) remains the most insidious barrier to success of Black faculty in our profession. We thus refocus attention on this critical barrier and suggest solutions on how it can be dismantled.
Microdissected “cuboids” for microfluidic drug testing of intact tissues
Image: A microfluidic platform that permits multiple drug testing of uniformly-sized microscale “cuboids” of live tissue with well-preserved microenvironments. Image by Dr. Albert Folch. Microdissected “cuboids” for microfluidic drug testing of intact tissues Lisa F. [...]
Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery
https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201800242 Jingxuan Yan, Ruying Chen, Hong Zhang, James D. Bryers. Macromol Biosci. 2019 Feb;19(2):e1800242. doi: 10.1002/mabi.201800242. Abstract: mRNA vaccines have proven to be more stable, effective, and specific than protein/peptide-based vaccines in stimulating both humoral and cellular immune response. However, mRNA's fast [...]
Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
Ying Zheng and colleagues demonstrate that engineered perfusable microvessel grafts enhance vascular remodeling and accelerate coronary perfusion, potentially supporting cardiac tissues after implantation.
Scaffold-Mediated Delivery for Non-Viral MRNA Vaccines
SCAFFOLD-MEDIATED DELIVERY FOR NON-VIRAL MRNA VACCINES https://www.nature.com/articles/s41434-018-0040-9 Ruying Chen, Hong Zhang, Jingxuan Yan, James D. Bryers Nature: Gene Therapy volume 25, pages556–567 (2018) ABSTRACT mRNA is increasingly being recognized as a promising alternative to pDNA in gene vaccinations. [...]
Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells
Kim Woodrow and colleagues demonstrate a LCNP that has the potential to co-deliver ARVs and mAbs for eradicating HIV reservoirs.