Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy
Ruikang Wang and colleagues demonstrate that swept-source OCTA may represent a new and noninvasive method for detecting and monitoring disease activity in BSCR.
Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates
Charles Murry and colleagues demonstrate that remuscularization of the infarcted macaque heart with human myocardium provides durable improvement in left ventricular function.
Cationic polymers for non-viral gene delivery to human T cells
Suzie Pun and colleagues We demonstrate transfection of both CD4+ and CD8+ primary human T cells with messenger RNA and plasmid DNA at efficiencies up to 25 and 18%, respectively, with similarly high viability.
A Carboxylate to Amide Substitution That Switches Protein Folds
Valerie Daggett and colleagues performed a comparative molecular dynamics study on the denatured states of two proteins, sharing nearly identical amino?acid sequences (88?%) but different topologies, namely an all?a?helical bundle protein named GA88 and an a+B?protein named GB88.
Analysis of the Myc-induced pancreatic B cell islet tumor microenvironment using imaging ToF-SIMS.
Lara Gamble and colleagues demonstrate that ToF-SIMS can be utilized to identify large-scale changes that occur in the tumor microenvironment and could thereby increase the understanding of tumor progression and the tumor microenvironment.
Macrophage-targeted drugamers with enzyme-cleavable linkers deliver high intracellular drug dosing and sustained drug pharmacokinetics against alveolar pulmonary infections
Patrick Stayton and colleagues demonstrate the versatility of the drugamer platform for engineering the intracellular pharmacokinetic profiles and its strong therapeutic activity in treating pulmonary intracellular infections.