Potential role of exosome-based allorecognition pathways involved in lung transplant rejection
Billanna Hwang, James Bryers, Michael S. Mulligan The Journal of Thoracic and Cardiovascular Surgery, Vol. 161, Issue 2, February 2021 | https://doi.org/10.1016/j.jtcvs.2020.04.183 Abstract Innate and adaptive immunity both contribute to allorecognition mechanisms that drive rejection [...]
Fund Black Scientists
Commentary with lead author Kelly Stevens: End funding discrimination.
Microdissected “cuboids” for microfluidic drug testing of intact tissues
Image: A microfluidic platform that permits multiple drug testing of uniformly-sized microscale “cuboids” of live tissue with well-preserved microenvironments. Image by Dr. Albert Folch. Microdissected “cuboids” for microfluidic drug testing of intact tissues Lisa F. [...]
Image-Guided Treatment of Primary Liver Cancer in Mice Leads to Vascular Disruption and Increased Drug Penetration
Sara B. Keller, Dingjie Suo, Yak-Nam Wang, Heidi Kenerson, Raymond S. Yeung and Michalakis A. Averkiou Frontiers in Pharmacology, 30 September 2020 | https://doi.org/10.3389/fphar.2020.584344 Abstract Despite advances in interventional procedures and chemotherapeutic drug development, hepatocellular carcinoma (HCC) [...]
Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery
https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201800242 Jingxuan Yan, Ruying Chen, Hong Zhang, James D. Bryers. Macromol Biosci. 2019 Feb;19(2):e1800242. doi: 10.1002/mabi.201800242. Abstract: mRNA vaccines have proven to be more stable, effective, and specific than protein/peptide-based vaccines in stimulating both humoral and cellular immune response. However, mRNA's fast [...]
Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
Ying Zheng and colleagues demonstrate that engineered perfusable microvessel grafts enhance vascular remodeling and accelerate coronary perfusion, potentially supporting cardiac tissues after implantation.