Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery Jingxuan Yan, Ruying Chen, Hong Zhang, James D. Bryers. Macromol Biosci. 2019 Feb;19(2):e1800242. doi: 10.1002/mabi.201800242. Abstract: mRNA vaccines have proven to be more stable, effective, and specific than protein/peptide-based vaccines in stimulating both humoral and cellular immune response. However, mRNA's fast [...]

  • scaffold-mediated delivery for non-viral mrna vaccines

Scaffold-Mediated Delivery for Non-Viral MRNA Vaccines

SCAFFOLD-MEDIATED DELIVERY FOR NON-VIRAL MRNA VACCINES Ruying Chen, Hong Zhang, Jingxuan Yan, James D. Bryers Nature: Gene Therapy volume 25, pages556–567 (2018) ABSTRACT mRNA is increasingly being recognized as a promising alternative to pDNA in gene vaccinations. [...]