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Featured Publications

  • Schematic and characterization of RNP8 and its intermediates

A ribonucleoprotein octamer for targeted siRNA delivery

Professor Xiaohu Gao and colleagues have created a new way to target prostate tumors that overcomes past challenges of designing effective drug delivery methods. This versatile nanocarrier design should offer opportunities for the clinical translation of therapies based on intracellularly acting biologics.

  • Schematic of the EASE technology

Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine

The researchers report a simple, universal "add-on" technology (EASE) that converts the ordinary sensitivities of common bioassays to extraordinary ones. They demonstrate that EASE facilitated increased sensitivity of ELISA-based detection of HIV, and enabled the direct visualization in tissues of the Zika virus and of low-abundance biomarkers for neurological diseases and cancer immunotherapy.

  • Demonstration of s. aureus biofilm structures and in the presence of anti-a-sheet peptide

Designed a-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms

The researchers have designed small proteins that can inhibit the formation of biofilms, common sources of infection for hundreds of patients worldwide, especially with those who have implanted medical devices. Their designed anti-a-sheet peptides suppressed the formation of biofilm in S. aureus, a bacteria resistant to many drugs, by about half, and prevented aggregation of infectious proteins through their binding mechanism.

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BioEngage

Connecting UW Bioengineers with Industry
We work closely with Industry Partners to build meaningful, mutually beneficial, and sustainable relationships.

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