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  • Composite fiber system: Mucus-penetrating nanoparticles encapsulated in mucoadhesive nanofibers. The system demonstrated greater than 30-fold increased nanoparticle retention in reproductive tract at 24 hr.

Nanoparticle-releasing nanofiber composites for enhanced in vivo vaginal retention

Current approaches for topical vaginal administration of nanoparticles result in poor retention and extensive leakage. To overcome these challenges, the researchers developed a nanoparticle-releasing nanofiber delivery platform and evaluated its ability to improve nanoparticle retention in a murine model. In this first study of nanoparticle releasing fibers for drug delivery, they discovered that the system demonstrated 30-fold increased nanoparticle retention in the reproductive tract 24 hours following administration.

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Connecting UW Bioengineers with Industry
We work closely with Industry Partners to build meaningful, mutually beneficial, and sustainable relationships.

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