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  • Global PiT-2 homozygous knockout mice exhibit reduced bone and tissue mineral density

Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice

The study's findings suggest that PiT-2 is involved in normal bone development and growth and plays roles in cortical and trabecular bone metabolism feasibly by regulating local phosphate transport and mineralization processes in the bone. Further studies that evaluate bone cell-specific loss of PiT-2 are now warranted and may yield insight into complex mechanisms of bone development and growth, leading to identification of new therapeutic options for patients with bone diseases.

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BioEngage

Connecting UW Bioengineers with Industry
We work closely with Industry Partners to build meaningful, mutually beneficial, and sustainable relationships.

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