I am Director of the Musculoskeletal Systems Biology Lab at the UW Institute for Stem Cell and Regenerative Medicine. We are understanding the genetic basis of osteoporosis, and identifying new therapeutic targets to combat this massive health burden. We are also working to understand why certain organisms are able to regenerate bony appendages following amputation, and how to mount this response in the digits and limbs of mammals. The Musculoskeletal Systems Biology Lab comprises engineers, basic scientists, and clinicians. Our focus is on taking bold, innovative approaches to reverse aging-induced bone fragility, and to help realize human regenerative potential.