Professor and Vice Dean of Research and Graduate Education, UW School of Medicine
Phone: 206-543-8320
Office: SLU C314

Shelly Sakiyama-Elbert

We are developing a library of cell lines to understand the cues required for differentiation and functional integration of key interneuron populations in the spinal cord.

Drug Delivery
Tissue Engineering
Stem Cells
Regenerative Medicine
Cellular Engineering

Our research program employs tissue and cellular engineering approaches to investigate biomedical problems. In particular, our lab is interested in the related areas of regenerative medicine, drug delivery, and stem cell biology with applications to therapies for spinal cord and peripheral nerve injury.

Ph.D. in Chemical Engineering from California Institute of Technology (2000)
M.S. in Chemical Engineering from California Institute of Technology (1998)
S.B. in Chemical Engineering and Biology from Massachusetts Institute of Technology (1996)

2018 American Society for Engineering Education (ASEE) Conference for Industry and Education Collaboration -College Industry Partnership Division – Best Session
2017 National Academy of Inventors – Fellow
2017 Clemson Award for Basic Research – Society for Biomaterials
2016 International Union of Societies of?Biomaterials Science and Engineering?- Fellow
2015 American Association for the Advancement of Science (AAAS) Fellow
2015 Outstanding Faculty Mentor – Graduate Student Senate (WUSTL)
2013 Distinguished Faculty Award – Washington University Founders Day
2013 Biomedical Engineering Society – Fellow
2011 American Institute for Biological and Medical Engineering – College of Fellows
2011 Excellence in Graduate Mentoring – Graduate Student Senate and Dean of the Graduate School of Arts & Sciences. (WUSTL)
2008 Dean’s Award for Excellence in Advising and Mentoring (WUSTL)
2006 Who’s Who in Technology – St. Louis Business Journal
2002 30 under 30 St. Louis Business Journal

1. Thompson RE, Pardieck J, Smith L, Kenny P, Crawford L, Shoichet, M, Sakiyama-Elbert S. Effect of Hyaluronic Acid Hydrogels Containing Astrocyte-Derived Extracellular Matrix and/or V2a Interneurons on Histologic Outcomes following Spinal Cord Injury. Biomaterials 162, 208-223, 2018.

2. Iyer N, Huettner JE, Butts JC, Brown CR and?Sakiyama-Elbert SE. Generation of Highly Enriched V2a Interneurons from Mouse Embryonic Stem Cells. Experimental Neurology, 277:305-16, 2016.

3. Marquardt LM, Ee X, Iyer N, Hunter DA, Wood MD,?Sakiyama-Elbert?SE. Finely Tuned Temporal and Spatial Delivery of GDNF Promotes Enhanced Nerve Regeneration in a Long Nerve Defect Model. Tissue Eng Part A, 21:2852-2864, 2015.

4. Wilems TS, Pardieck J, Iyer N, Sakiyama-Elbert SE. Combination Therapy of Stem Cell Derived Neural Progenitors and Drug Delivery of Anti-Inhibitory Molecules for Spinal Cord Injury. Acta Biomaterialia, 28:23-32, 2015.

5. Jesuraj NJ, Santosa KB, MacEwan MR, Moore AM, Kasukurthi R, Ray WR, Flagg ER, Hunter DA, Borschel GH, Johnson PJ, Mackinnon SE, and Sakiyama-Elbert SE. “Schwann Cells Seeded in Acellular Nerve Grafts Improve Functional Recovery”. Muscle and Nerve 49(2):267-76, 2014.

6. Wood, MD, MacEwan MR, French AR, Moore, AM, Hunter, Mackinnon, SE, Moran DW, Borschel, GH, and Sakiyama-Elbert, SE. Fibrin Matrices with Affinity-based Delivery Systems and Neurotrophic Factors Promote Functional Nerve Regeneration. Biotechnology and Bioengineering 106:970-979, 2010.

7. Johnson, PJ, Tatara, A, Shiu, A, Sakiyama-Elbert, SE. Controlled release of neurotrophin-3 and platelet derived growth factor from fibrin scaffolds containing neural progenitor cells enhances survival and differentiation into neurons in a subacute model of SCI.? Cell Transplantation 19: 89-101, 2010.

8. Willerth, SM, Faxel, TE, Gottlieb, D, and Sakiyama-Elbert, SE.? The Effects of Soluble Growth Factors on Embryonic Stem Cell Differentiation Inside of Fibrin Scaffolds.?Stem Cells 25(9):2235-2244, 2007.

9. Taylor, SJ, Rosenzweig, ES, McDonald, JW, Sakiyama-Elbert, SE. Controlled Delivery of Neurotrophin-3 from Fibrin Scaffolds Enhances Neural Fiber Sprouting After Spinal Cord Injury. Journal of Controlled Release 113:225-235, 2006.

10. Lee, AC, Yu, VM, Lowe, JB, Brenner, MJ, Hunter, DA, Mackinnon, SE, and Sakiyama-Elbert, SE. Controlled Release of Nerve Growth Factor Enhances Sciatic Nerve Regeneration. Experimental Neurology 184(1): 295-303, 2003.

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