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  • : Deficiency or inhibition of S1P lyase results in higher bone mass and strength, altered OC activity and increased plasma OPG

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Research Associate Professor Marta Scatena and a team of collaborators show that raising Sphingosine-1-phosphate (S1P) levels in adult mice through conditionally deleting or pharmacologically inhibiting S1P lyase, the sole enzyme responsible for irreversibly degrading S1P, markedly increased bone formation, mass and strength and substantially decreased white adipose tissue.

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Connecting UW Bioengineers with Industry
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