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  • Human heart model made of red paper

Engineering solutions for heart health

At the UW Institute for Stem Cell and Regenerative Medicine (ISCRM), researchers are unraveling the mysteries of the human heart through innovative engineering

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Featured Publications

  • Coculture of marrow fibroblasts with engineered vessels create perfusable marrow microenvironments

Engineering a multicellular vascular niche to model hematopoietic cell trafficking

Assistant Professor Ying Zheng and colleagues developed an engineered human vascular marrow niche to examine the three-dimensional cell interactions that direct hematopoietic cell trafficking. The platform provides a tool to advance study of the interactions between endothelial cells, marrow-derived fibroblasts and hematopoeitic cells that comprise the marrow vascular niche, and has potential for use in testing therapeutics and personalized medicine.

  • Graphical abstract of Human Organ-Specific Endothelial Cell Heterogeneity

Human Organ-Specific Endothelial Cell Heterogeneity

BioE faculty Charles Murry, Kelly Stevens and Ying Zheng, and interdisciplinary colleagues from across UW, investigated the properties of endothelial cells (ECs), isolated from four human major organs—the heart, lung, liver, and kidneys—in individual fetal tissues at three months' gestation, at gene expression, and at cellular function levels. Their findings showed the link between human EC heterogeneity and organ development and can be exploited therapeutically to contribute in organ regeneration, disease modeling, as well as guiding differentiation of tissue-specific ECs from human pluripotent stem cells.

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Researchers examining equipment in labTogether, we are pursuing discoveries, treatments and tools that invent the future of medicine. You can help us transform lives here in Washington and around the world.

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BioEngage

BioEngage

Connecting UW Bioengineers with Industry
We work closely with Industry Partners to build meaningful, mutually beneficial, and sustainable relationships.

BioEngage