Project Description

Hunter and Dorothy Simpson Endowed Chair of Bioengineering
Professor, UW Bioengineering
pii@uw.edu

Princess Imoukhuede

Our lab pioneers both quantitative biological measurements and computational biological models to delineate signal transduction. This bottom-up systems biology paradigm offers mechanistic insight primarily towards directing vascular signaling and analyzing oxytocin receptor variants with translational implications to cancers and cardiovascular diseases and women’s health.

Vascular health: Endothelial phenotyping and vascular pathology measurement via VEGFR quantification

Systems analysis and prediction of endothelial cross-family signaling

Women’s health: Improving the efficacy and safety for oxytocin use in labor and delivery

Blood vessels supply the nutrients necessary for organ & tissue function—every action is dependent upon a healthy, intact vasculature. Indeed, over 70 diseases are angiogenesis-related. Cancers represent a well-known angiogenesis-related disease. Here, abnormal blood vessels sustain tumor growth, development, and metastasis. However, anti-angiogenic therapies only moderately affect patient survival, ultimately leading to patient resistance.

We believe that unraveling vascular signaling complexities can occur by engineering quantitative experimental tools and computational models. Our research directly addresses this need, applying a “bottom-up,” systems biology paradigm to measure, integrate, and simulate mechanisms regulating angiogenesis.

SB, Chemical Engineering, MIT
PhD, Bioengineering, Caltech

Postdoctoral Fellowship, Biomedical Engineering, Johns Hopkins University

University of Pittsburgh Graduate Women in Engineering Network, High Impact Innovation and Inspiration (HI3) Speaker Award , 2020
AIChE Journal Futures Series, 2019
Bionanotechnology, Young Innovator, 2018
Illinois Mathematics and Science Academy (IMSA), Distinguished Leadership Award, 2018
NSF CAREER Award, 2017
Rose Award for Teaching Excellence, 2017
Cellular and Molecular Bioengineering Young Innovator, 2015
NIH-NIDDK, Basic Research Award, 2015
American Cancer Society, Illinois Division, Basic Research Grant, 2013-2015
Gordon Conference in Angiogenesis Poster Award, 2011
NIH Loan Repayment Awardee for Clinical Research, 2009
UNCF/Merck Postdoctoral Research Fellowship, 2008
Commitment to Diversity Award, Caltech, 2008

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