Precision-porous templated scaffolds of varying pore size drive dendritic cell activation
The Bryers labs presents the effects of varying pore size of poly (2-hydroxyethyl methacrylate) (pHEMA) and poly(dimethylsiloxane) (PDMS, silicone) scaffolds on the maturation and in vivo enrichment of dendritic cells.
Zwitterionic Nanocages Overcome the Efficacy Loss of Biologic Drugs
Researchers from Shaoyi Jiang's (BioE adjunct) lab demonstrate a zwitterionic polycarboxybetaine nanocage that can physically encase proteins while keeping their structure intact. This approach addresses the problem posed by efficacy loss of biotherapeutics due to undesirable immune response.
Noncovalent tagging of siRNA with steroids for transmembrane delivery
The Gao lab reports on the development of small, bifunctional chemical tags capable of transporting siRNA directly into the cytosol. The bifunctional tags consist of a siRNA-binding moiety that interacts with siRNA non-covalently, and a steroid domain that readily fuses with the mammalian cell membrane.
Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues
Deok-Ho Kim's lab demonstrates that biomimetic nanotopography and S1P can be combined to synergistically regulate the maturation and vascularization of engineered skeletal muscles.
Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model
The Scatena and Giachelli labs developed an animal model that mimicked the structural and functional features of CAVD in people with T2DM, by testing a diabetogenic, procalcific diet and its effect on the incidence and severity of CAVD and AS in the, LDLr-/-ApoB100/100 mouse model.
Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
The researchers compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.