Research Associate Professor
Office: MolES 226
Mass Spectral Imaging
Our work and advances in ToF-SIMS imaging and data processing has prompted significant interest among biomedical academic as well as the clinical research community. Utilizing the newer cluster ion sources allows us to get 3-D images of cells and tissues as well. We continue to further advancement in this area with the addition of new instrumentation as well as improved data processing. Newer advancements have involved image registration to correlate image data acquired on different techniques and statistical analysis of multiple data.
BA, University of California, Santa Cruz
Senior Scientist, Space Dynamics Laboratory
2014 Peter M.A. Sherwood Mid Career Award (AVS-Applied Surface Science Division)
2013-2015 USA Representative, IUVSTA Biointerfaces Division
2014 Peter M.A. Sherwood Mid Career Award (AVS)
2011-2012 Chair, Biomaterials Interfaces Division, AVS
2010-2011 Program Chair, Biomaterials Interfaces Division, AVS
1993 UW Department of Chemistry David M. Ritter Graduate Student Award
B. Bluestein, D. J. Graham, F. Morrish, J. Guenthoer, D. Hockenbery, and P. Porter, L. J. Gamble*, “An Unsupervised MVA Method to Compare Specific Regions in Human Breast Tumor Tissue Samples Using ToF-SIMS”. Analyst. 2016 Mar 7;141(6):1947-57. doi: 10.1039/c5an02406d. PubMed PMID: 26878076; PubMed Central PMCID: PMC4783233.
M. A. Robinson, D. J. Graham, F. Morrish, D. Hockenbery and L. J. Gamble*, “Lipid analysis of eight human breast cancer cell lines with TOF-SIMS”. Biointerphases 2016, 11, 02A303: http://dx.doi.org/10.1116/1.4929633: PMCID: PMC4552699
L. J. Gamble*, D. J. Graham, B. Bluestein, N. P. Whitehead, D. Hockenbery, F. Morrish and P. Porter “ToF-SIMS of tissues: “Lessons learned” from mice and women”. Biointerphases 2015, 10, 019008: http://dx.doi.org/10.1116/1.4907860: PMCID: PMC4327923
A. Harrison, H. Binder, A. Buhot, C. J. Burden, E. Carlon, C. Gibas, L. J. Gamble, A. Halperin, J. Hooyberhs, D. P. Kreil, R. Levicky, P. A. Novel, A. Ott, B. M. Pettitt, D. Tautz, A. E. Pozhitkov, “Physico-chemical Foundations underpinning microarray and next-generation sequencing experiments”, Nucleic Acids Research, 2013, 1-18. DOI:10.1093/nar/gks1358
Archana N. Rao, Nicolas Vandencasteele, Lara J. Gamble, and David W. Grainger, “High-Resolution Epifluorescence and Time-of-Flight Secondary Ion Mass Spectrometry Chemical Imaging Comparisons of Single DNA Microarray Spots”, Analytical Chemistry 2012 84 (24), 10628-10636. DOI: 10.1021/ac3019334
C.-Y. Lee, P. Gong, G.M. Harbers, D.W. Grainger, D.G. Castner, and L.J. Gamble, “Surface Coverage and Structure of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by XPS, NEXAFS, and Fluorescence Intensity Measurements”, Anal. Chem., 78, p3316-3325, 2006.
P. Gong, C.-Y. Lee, L.J. Gamble, D.G. Castner, and D.W. Grainger, “Hybridization Behavior of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by Surface Plasmon Resonance and 32P Radiometric Assay”, Anal. Chem., 78, p3326-3334, 2006