Associate Professor
yingzy@uw.edu
Phone: (206) 543-3223
Office: South Lake Union campus, 820 Republican St., Brotman Building, Room 421
UW Bioengineering faculty Ying Zheng

Ying Zheng

Lab Website

How I am inventing the future of medicine

We are building human tissue and organ systems in vitro to study the fundamentals of human diseases, develop therapies, and regenerate human cells, tissues and organs.

Vascular Biology and Engineering
Living Microfluidics
Regenerative Medicine
Organ on a chip for disease modeling
Blood-endothelium interactions

The goal of our research program is to understand and engineer the fundamental structure and functions in living tissue and organ systems of our human body from nanometer, micrometer to centimeter scale. The fundamentals and technology requirements of our program includes a mixture of biomechanics, transport phenomena, microfluidic technologies, and biology and medicine. The success of our research achievement may lead towards clinical applications for regenerative tissue and organs, and therapeutic applications and health industry with deconstructive in vivo-mimiking models

Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, 2008
B.S., Engineering Thermophysics, University of Science and Technology of China, 2002

Postdoctoral Training, Chemical and Biomolecular Engineering, Cornell University, 2011

2013 National Institute of Health Director’s New Innovator Award
2011 American Heart Association Scientist Development Award

BIOEN 325 Biotransport
BIOEN 483/583 Vascular Biology and Engineering
BIOEN 327 Fluids and Materials Laboratory

1. Howard C, Joof F, Hu R, Smith JD, Zheng Y. Probing cerebral malaria inflammation in 3D human brain microvessels. Cell Reports, 2023, 42(10):113253.
2. Zeinstra N, Frey AL, Xie Z, Blakely LP, Wang RK, Murry CE, Zheng Y. Stacking thick perfusable human microvascular grafts enables dense vascularity and rapid integration into infarcted rat hearts, Biomaterials, 2023, 301:122250.
3. YJ Shin, KM Evitts, S Jin, CC Howard, M Sharp-Milgrom, JE Young, Zheng Y. Amyloid beta peptides (A?) from Alzheimer’s disease neuronal secretome induce endothelial activation in a human cerebral microvessel model. Neurobiology of Disease, 2023, 181:106125.
4. Rayner SG, Scholl Z, Mandrycky CJ, Chen J, LaValley KN, Leary PJ, Altemeier WA, Liles WC, Chung DW, Lopez JA, Fu H, Zheng Y., Endothelial-derived von Willebrand Factor Accelerates Fibrin Clotting within Engineered Microvessels, JTH, 2022.
5. Rayner S, Howard C, Mandrycky C, Stamenkovic S, Himmelfarb J, Shih A, Zheng Y, Multiphoton-guided creation of complex organ-specific microvasculature, Adv. H. Mat., 2021, 10(10): e2100031.
6. Mandrycky C, Hadland B, Zheng Y. 3D curvature-instructed endothelial flow response and tissue vascularization, Science Advances, 2020,6(38), eabb3629. [PMC7494348] 7. Arakawa C, Gunnarsson C, Howard C, Bernabeu M, Phong K, Yang E, DeForest CA, Smith JD, Zheng Y, Biophysical and Biomolecular Interactions of Malaria-Infected Erythrocytes in Engineered Human Capillaries, Science Advances, 2020, 6(3), eaay7243 DOI: 10.1126/sciadv.aay7243.
8. Nagao R, Marcu R, Wang Y, Wang L, Arakawa C, Deforest CA, Chen J, Lopez JA, Zheng Y, Transforming Endothelium with Platelet-Rich Plasma in Engineered Microvessels, Advanced Science, 2019, doi.org/10.1002/advs.201901725
9. Redd MA, Zeinstra N, Qin W, Wei W, Martinson A, Wang RK, Murry CE, Zheng Y, “Patterned human microvascular grafts enable rapid anastomosis and increase perfusion in infarcted hearts”, 2019, Nature Communications, 10, 584.
10. Marcu R, Choi YJ, Xue J, Fortin CL, Wang Y, Nagao R, Xu J, MacDonald J, Bammler T, Murry CE, Muczynski K, Stevens KR, Himmelfarb J, Schwartz SM, Zheng Y, “Human Organ-specific Endothelial Cell Heterogeneity “, iScience, 2018 , Volume 4 , 20 – 35.
11. Palpant, N.J., Pabon, L., Friedman C.E., Roberts, M., Hadland, B., Zaunbrecker, B., Bernstein, I., Zheng, Y., Murry, C.E.,” Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells”, Nature Protocol, 12, 15–31, 2017.
12. Ligresti, G., Nagao, R.J., Xue, J., Choi, Y.J., Xu, J., Ren, S., Aburatani., T., Anderson, S.K., MacDonald, J.W., Bammler, T.K., Schwartz, S. W., Muczynski, K. A., Duffield, D. S., Himmelfarb, J and Zheng, Y., “A novel three-dimensional human peritubular microvascular system.”. JASN, 2015, doi: 10.1681/ASN.2015070747.
13. Zheng, Y.*, Chen, J., Lopez, J.A.*, “Flow Driven assembly of VWF fibers and webs in in vitro microvessels”, Nature Communications, 6: 7858, 2015. PMID: 26223854. (* corresponding author)
14. Zheng, Y.*, Chen, J., Craven, M., Choi, N.W., Totorica, S., Diaz-Santana, A., Kermanie, P., Hempsteade, B., Fischbach-Teschl, C., Lopez, J.A., Stroock, A.D.*, 2012, “In vitro microvessels for the study of angiogenesis and thrombosis.” Proceedings of the National Academy of Science, 109(24), 9342-9347. (* corresponding author)

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