Featured Publications

Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers

The researchers report a pH-sensitive polymer, p(PMA-PMBA)-b-p(OEGMA-DMAEMA) (SP), and its successful use in vitro and in vivo gene transfer. The polymer addresses the dilemma of stability and cargo release in gene delivery, and may have broad potential therapeutic agent delivery applications.

2020-10-26T08:29:24-07:00March 22nd, 2017|

Single-use paper-based hydrogen fuel cells for point-of-care diagnostic applications

The researchers demonstrate a stand-along power source that integrates a paper-based hydrogen fuel cell with a customized chemical heater that produces hydrogen in-situ upon the addition of a liquid. Their approach could power portable diagnostics and enable functionality such as device timing, actuation and signal quantification.

2020-10-26T08:29:24-07:00March 21st, 2017|

Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo

The researchers demonstrate that optical coherence tomography (OCT)-based microangiography (OMAG) is a promising imaging tool for longitudinal study of collateral vessel remodeling in small animals, and can be applied in guiding the in-vivo experiments of arteriogenesis stimulation to treat occlusive vascular diseases, including stroke.

2020-10-26T08:29:24-07:00March 21st, 2017|

Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity

The researchers demonstrate acoustic micro-tapping – the use of focused ultrasound propagating in air to generate transient mechanical waves – as a non-invasive approach to dynamic elastography for mapping the elasticity of biological tissue without any physical contact. They propose to use it with 4-D phase-sensitive optical coherence tomography to create a tool for ophthalmology, dermatology and other applications where direct contact with the tissue being studied may be undesirable.

2020-10-26T08:29:45-07:00January 6th, 2017|

Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation

The researchers investigate the importance of Runx2 (runt-related transcription factor-2) in turning vascular smooth muscle cells into bone and cartilage cells, contributing to arterial intimal calcification, a condition implicated in atherosclerosis and may contribute to heart attack, stroke and other cardiovascular events.

2020-10-26T08:29:45-07:00December 23rd, 2016|

Microvascular Injury and Perfusion Changes Induced by Ultrasound and Microbubbles in a Machine-Perfused Pig Liver

The researchers combined ex vivo machine-perfused pig livers with an image-guided therapy system to investigate applications of ultrasound-driven microbubbles to enhance drug delivery, and demonstrate a versatile, physiologically relevant platform for pre-clinical research.

2020-10-26T08:29:45-07:00January 4th, 2017|

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue

The researchers demonstrate how electric pacing and mechanical stimulation promote maturation of the structural, mechanical and force generation properties of human-induced pluriopotent stem cell-derived cardiac tissues.

2020-10-26T08:29:46-07:00December 21st, 2016|
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