Featured Publications

/Featured Publications

Featured Publications from UW Bioengineering

Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells

Kim Woodrow and colleagues demonstrate a LCNP that has the potential to co-deliver ARVs and mAbs for eradicating HIV reservoirs.

By | January 2nd, 2019|

Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy

Ruikang Wang and colleagues demonstrate that swept-source OCTA may represent a new and noninvasive method for detecting and monitoring disease activity in BSCR.

By | January 2nd, 2019|

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

Charles Murry and colleagues demonstrate that remuscularization of the infarcted macaque heart with human myocardium provides durable improvement in left ventricular function.

By | January 2nd, 2019|

Cationic polymers for non-viral gene delivery to human T cells

Suzie Pun and colleagues We demonstrate transfection of both CD4+ and CD8+ primary human T cells with messenger RNA and plasmid DNA at efficiencies up to 25 and 18%, respectively, with similarly high viability.

By | January 2nd, 2019|

A Carboxylate to Amide Substitution That Switches Protein Folds

Valerie Daggett and colleagues performed a comparative molecular dynamics study on the denatured states of two proteins, sharing nearly identical amino?acid sequences (88?%) but different topologies, namely an all?a?helical bundle protein named GA88 and an a+B?protein named GB88.

By | January 2nd, 2019|

Analysis of the Myc-induced pancreatic B cell islet tumor microenvironment using imaging ToF-SIMS.

Lara Gamble and colleagues demonstrate that ToF-SIMS can be utilized to identify large-scale changes that occur in the tumor microenvironment and could thereby increase the understanding of tumor progression and the tumor microenvironment.

By | January 2nd, 2019|

Macrophage-targeted drugamers with enzyme-cleavable linkers deliver high intracellular drug dosing and sustained drug pharmacokinetics against alveolar pulmonary infections

Patrick Stayton and colleagues demonstrate the versatility of the drugamer platform for engineering the intracellular pharmacokinetic profiles and its strong therapeutic activity in treating pulmonary intracellular infections.

By | January 2nd, 2019|

A ribonucleoprotein octamer for targeted siRNA delivery

Professor Xiaohu Gao and colleagues have created a new way to target prostate tumors that overcomes past challenges of designing effective drug delivery methods. This versatile nanocarrier design should offer opportunities for the clinical translation of therapies based on intracellularly acting biologics.

By | July 4th, 2018|

Mobile Phone Ratiometric Imaging Enables Highly Sensitive Fluorescence Lateral Flow Immunoassays without External Optical Filters

Professor Paul Yager's lab has created a method that enables optical-filter free mobile imaging for medical diagnostics, a first step towards enabling a new generation of highly sensitive, point-of-care fluorescence assays.

By | July 4th, 2018|

Desktop-Stereolithography 3D-Printing of a Poly(dimethylsiloxane)-Based Material with Sylgard-184 Properties

Professor Albert Folch's lab reports on the formulation, characterization, and SL application of a 3D?printable PDMS resin (3DP?PDMS) based on commercially available PDMS?methacrylate macromers, a high?efficiency photoinitiator and a high?absorbance photosensitizer. 3DP?PDMS resin enables assembly?free, automated, digital manufacturing of PDMS, which should facilitate the prototyping of devices for microfluidics, organ?on?chip platforms, soft robotics, flexible electronics, and sensors, among others.

By | July 4th, 2018|