Featured Publications

/Featured Publications

Featured Publications from UW Bioengineering

Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery

https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201800242 Jingxuan Yan, Ruying Chen, Hong Zhang, James D. Bryers. Macromol Biosci. 2019 Feb;19(2):e1800242. doi: 10.1002/mabi.201800242. Abstract: mRNA vaccines have proven to [...]

By | June 6th, 2019|

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Ying Zheng and colleagues demonstrate that engineered perfusable microvessel grafts enhance vascular remodeling and accelerate coronary perfusion, potentially supporting cardiac tissues after implantation.

By | February 28th, 2019|

Scaffold-Mediated Delivery for Non-Viral MRNA Vaccines

SCAFFOLD-MEDIATED DELIVERY FOR NON-VIRAL MRNA VACCINES https://www.nature.com/articles/s41434-018-0040-9 Ruying Chen, Hong Zhang, Jingxuan Yan, James D. [...]

By | February 19th, 2019|

Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells

Kim Woodrow and colleagues demonstrate a LCNP that has the potential to co-deliver ARVs and mAbs for eradicating HIV reservoirs.

By | January 2nd, 2019|

Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy

Ruikang Wang and colleagues demonstrate that swept-source OCTA may represent a new and noninvasive method for detecting and monitoring disease activity in BSCR.

By | January 2nd, 2019|

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

Charles Murry and colleagues demonstrate that remuscularization of the infarcted macaque heart with human myocardium provides durable improvement in left ventricular function.

By | January 2nd, 2019|

Cationic polymers for non-viral gene delivery to human T cells

Suzie Pun and colleagues We demonstrate transfection of both CD4+ and CD8+ primary human T cells with messenger RNA and plasmid DNA at efficiencies up to 25 and 18%, respectively, with similarly high viability.

By | January 2nd, 2019|

A Carboxylate to Amide Substitution That Switches Protein Folds

Valerie Daggett and colleagues performed a comparative molecular dynamics study on the denatured states of two proteins, sharing nearly identical amino?acid sequences (88?%) but different topologies, namely an all?a?helical bundle protein named GA88 and an a+B?protein named GB88.

By | January 2nd, 2019|

Analysis of the Myc-induced pancreatic B cell islet tumor microenvironment using imaging ToF-SIMS.

Lara Gamble and colleagues demonstrate that ToF-SIMS can be utilized to identify large-scale changes that occur in the tumor microenvironment and could thereby increase the understanding of tumor progression and the tumor microenvironment.

By | January 2nd, 2019|

Macrophage-targeted drugamers with enzyme-cleavable linkers deliver high intracellular drug dosing and sustained drug pharmacokinetics against alveolar pulmonary infections

Patrick Stayton and colleagues demonstrate the versatility of the drugamer platform for engineering the intracellular pharmacokinetic profiles and its strong therapeutic activity in treating pulmonary intracellular infections.

By | January 2nd, 2019|