Featured Publications from UW Bioengineering
Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers
Yilong Chen, Drew L. Sellers, James-Kevin Y. Tan, David J. Peeler, Philip J. Horner, Suzie H. Pun. Biomaterials. Volume 127, May 2017, Pages 89-96. The researchers report a pH-sensitive polymer, p(PMA-PMBA)-b-p(OEGMA-DMAEMA) (SP), and its successful use in vitro and in vivo gene transfer. The polymer addresses the dilemma of stability and cargo release in gene delivery, and may have broad potential therapeutic agent delivery applications.
J.P. Esquivel, J.R. Buser, C.W. Lim, C. Domínguez, S. Rojas, P. Yager, N. Sabaté. Journal of Power Sources. Volume 342, 28 February 2017, Pages 442-451. The researchers demonstrate a stand-along power source that integrates a paper-based hydrogen fuel cell with a customized chemical heater that produces hydrogen in-situ upon the addition of a liquid. Their approach could power portable diagnostics and enable functionality such as device timing, actuation and signal quantification.
miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria
Kevin R Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L Conroy, Michael Hawkes, Henry S Cheng, Makon-Sébastien Njock, Jason E Fish, John M Harlan, Jose A López, W Conrad Liles, and Kevin C Kain. Molecular Medicine. 2017 February 2; 23. The researchers demonstrate that miR-155 has a mechanistic role in host response to malaria via regulation of endothelial activation, microvascular leak and blood brain barrier (BBB) dysfunction in cerebral malaria (CM).
Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo
Yuandong Li, Woo June Choi, Wan Qin, Utku Baran, Lauren M. Habenicht, Ruikang K. Wang. Journal of Neuroscience Methods. Volume 274, 1 December 2016, Pages 164-172. The researchers demonstrate that optical coherence tomography (OCT)-based microangiography (OMAG) is a promising imaging tool for longitudinal study of collateral vessel remodeling in small animals, and can be applied in guiding the in-vivo experiments of arteriogenesis stimulation to treat occlusive vascular diseases, including stroke.
Facile fabrication of tissue-engineered constructs using nanopatterned cell sheets and magnetic levitation
Nisa Penland, Eunpyo Choi, Mikael Perla, Jungyul Park and Deok-Ho Kim. Nanotechnology, Volume 28, Number 7 (2017). The researchers describe a novel method for fabricating scaffold-free tissue-engineered constructs using thermoresponsive nanofabricated substrates (TNFS) and magnetic levitation.
?ukasz Ambrozi?ski, Shaozhen Song, Soon Joon Yoon, Ivan Pelivanov, David Li, Liang Gao, Tueng T. Shen, Ruikang K. Wang, Matthew O’Donnell. Scientific Reports, 6: 38967 (2016). The researchers demonstrate acoustic micro-tapping – the use of focused ultrasound propagating in air to generate transient mechanical waves – as a non-invasive approach to dynamic elastography for mapping the elasticity of biological tissue without any physical contact. They propose to use it with 4-D phase-sensitive optical coherence tomography to create a tool for ophthalmology, dermatology and other applications where direct contact with the tissue being studied may be undesirable.
Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation
Mu-En Lin, Theodore M. Chen, Mary C. Wallingford, Ngoc B. Nguyen, Shunsuke Yamada, Chenphop Sawangmake, Jaimei Zhang, Mei Y. Speer, Cecilia M. Giachelli. Cardiovascular Research. The researchers investigate the importance of Runx2 (runt-related transcription factor-2) in turning vascular smooth muscle cells into bone and cartilage cells, contributing to arterial intimal calcification, a condition implicated in atherosclerosis and may contribute to heart attack, stroke and other cardiovascular events.
Lisa K. Lafleur, et al. Lab on a Chip, 2016, 16, 3777-3787. The researchers demonstrate a prototype of MAD NAAT, the first fully integrated, sample-to-result diagnostic platform for performing nucleic acid amplification texts that require no permanent instrument or manual sample processing.
Microvascular Injury and Perfusion Changes Induced by Ultrasound and Microbubbles in a Machine-Perfused Pig Liver
Christina P. Keravnou, Ine De Cock, Ine Lentacker, Maria-Louisa Izamis, Michalakis A. Averkiou. Ultrasound in Medicine & Biology, 2016 Nov;42(11):2676-2686. The researchers combined ex vivo machine-perfused pig livers with an image-guided therapy system to investigate applications of ultrasound-driven microbubbles to enhance drug delivery, and demonstrate a versatile, physiologically relevant platform for pre-clinical research.
Sharmishtaa Seshamani, Anna I. Blazejewska, Susan Mckown, Jason Caucutt, Manjiri Dighe, Christopher Gatenby, Colin Studholme Human Brain Mapping, Nov 2016, 37(11), 4158-4178. The researchers describe an fMRI processing and analysis framework for multiecho fetal brain studies where head motion cannot be controlled.